Figure 3.
Figure 3. Engineering unique Kir2.1 contacts into inactivating mutant Kir6.2 channels. Macroscopic KATP channel current responses to ATP (1 mM, gray lines) in excised patches. Arrows indicate the first application of PIP2 (5 µg/ml), which was then present for the remaining duration of the recording. * indicates potential repulsion between sidechains.

Engineering unique Kir2.1 contacts into inactivating mutant Kir6.2 channels. Macroscopic KATP channel current responses to ATP (1 mM, gray lines) in excised patches. Arrows indicate the first application of PIP2 (5 µg/ml), which was then present for the remaining duration of the recording. * indicates potential repulsion between sidechains.

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