Figure 12. Large K and Cs currents carried by nystatin channels project to similar mixing volumes as results for Na currents. (A) Nystatin-carried K current. Extracellular NMDG was replaced by K and 60 µM nystatin was applied, generating an inward current of ∼1.7 nA. The outward current activated by removing K amounted to 0.3 nA and decayed with a time constant of 14.4 s. The fractional decay of inward current is less than for equivalent Na currents (or for K currents in veratridine-modified Na channels), and the mean τ of current decay is 17.5 s. The projected mixing volume is 10.1 pL. (B) Nystatin-carried Cs current. In the presence of 50 µM nystatin, extracellular NMDG was replaced with Cs multiple times, activating peak inward currents of ∼1.6 nA. Currents decayed with a mean τ of 13.5 s, projecting to a mixing volume of 10.8 pL.
Figure 12.

Large K and Cs currents carried by nystatin channels project to similar mixing volumes as results for Na currents. (A) Nystatin-carried K current. Extracellular NMDG was replaced by K and 60 µM nystatin was applied, generating an inward current of ∼1.7 nA. The outward current activated by removing K amounted to 0.3 nA and decayed with a time constant of 14.4 s. The fractional decay of inward current is less than for equivalent Na currents (or for K currents in veratridine-modified Na channels), and the mean τ of current decay is 17.5 s. The projected mixing volume is 10.1 pL. (B) Nystatin-carried Cs current. In the presence of 50 µM nystatin, extracellular NMDG was replaced with Cs multiple times, activating peak inward currents of ∼1.6 nA. Currents decayed with a mean τ of 13.5 s, projecting to a mixing volume of 10.8 pL.

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