Figure 1.
Figure 1. Ligand-sensing residues in the inner-pore region of Nav1.x channels. (A) Ligands considered in this study. (B) Sequences alignment of NavMs and Nav1.4. Key positions where mutations affect action of inner pore blockers (Mike and Lukacs, 2010) are highlighted. (C) The NavMs structure. Shown are Cα-Cβ bonds in key ligand-sensing residues and NaIII. Repeats I, III, and IV are blue, green, and orange, respectively. Repeat II is not depicted for clarity. Red ovals mark approximate borders of the selectivity filter region (1), the inner pore region (2), the activation gate region (3), and two of the four repeat interfaces (4).

Ligand-sensing residues in the inner-pore region of Nav1.x channels. (A) Ligands considered in this study. (B) Sequences alignment of NavMs and Nav1.4. Key positions where mutations affect action of inner pore blockers (Mike and Lukacs, 2010) are highlighted. (C) The NavMs structure. Shown are Cα-Cβ bonds in key ligand-sensing residues and NaIII. Repeats I, III, and IV are blue, green, and orange, respectively. Repeat II is not depicted for clarity. Red ovals mark approximate borders of the selectivity filter region (1), the inner pore region (2), the activation gate region (3), and two of the four repeat interfaces (4).

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