Reduced glucose sensitivity of K_ATP conductance in Kir6.1-GOF islets. (A) Glucose- and glibenclamide-dependent Rb⁺ effluxes from BAC-Kir6.1[WT] (blue) and BAC-Kir6.1[GD] (pink) islets. (B) Rate constant for Rb⁺ efflux at each condition (k_test), normalized to rate constant in 1 mM glucose (k_1G), in BAC-Kir6.1[WT] and BAC-Kir6.1[GD] islets. Data represent mean ± SEM, n = 4 mice (n > 50 islets per sample) in each group.