Impaired glucose-dependent insulin secretion in BAC-Kir6.1[GD] transgenic mice. Glucose-dependent insulin secretion on isolated islets from BAC-Kir6.1[GD] and BAC-Kir6.1[WT] mice. Batches of 10 islets were statically preincubated in low glucose and then incubated in various glucose concentrations, or in glibenclamide, or in KCl for 1 h. Data represent mean ± SEM, n = 4–5 mice in each group. Significant differences (*, P < 0.05) between transgenic and control littermates under the same condition are indicated (t test).