The geometry of the model NPC. (A) The anchor site of each NPC filament indicates the attachment position along the nuclear–cytoplasmic axis of each FG-Nup with the NPC geometry. The lengths of FG-Nups correspond to the size of the unstructured portions of the primary amino acid sequence. The black lines indicate FG-repeat locations. These FG-Nups are found in eightfold symmetry, anchored around the scaffold of the NPC. (B) Plotted snapshot of our simulation; all axes are in nanometers.