Figure 1.
Figure 1. Channels underlying If “funny current” open with hyperpolarization (left along x axis). Aging causes a left (negative) shift in the G-Vm relation (orange), with a corresponding reduction in If at a given voltage and slowing of pacemaker cell action potential frequency (and heart rate). cAMP applied exogenously can overcome the effects of aging on If, shifting the G-Vm to more positive voltages characteristic of the young pacemaker cells with a corresponding increase in pacemaker cell firing rates. Adapted from Sharpe et al. (2017).

Channels underlying If “funny current” open with hyperpolarization (left along x axis). Aging causes a left (negative) shift in the G-Vm relation (orange), with a corresponding reduction in If at a given voltage and slowing of pacemaker cell action potential frequency (and heart rate). cAMP applied exogenously can overcome the effects of aging on If, shifting the G-Vm to more positive voltages characteristic of the young pacemaker cells with a corresponding increase in pacemaker cell firing rates. Adapted from Sharpe et al. (2017).

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