Figure 5.
![Figure 5. The ethanol response of β2-IR–containing BK channels is similar to the ethanol response of cbv1+β1 channels. (A) V0.5 versus [Ca2+]i plot showing that the activation to inhibition crossover for ethanol effect on cbv1+β2-IR channels occurs at ≈3 µM Ca2+i, as found with cbv1±β1 (Fig. 3 D) and wt β2 (Fig. 4 C). (B) Bar graph showing ethanol-induced change in V0.5 values from control obtained at 0.3 and 100 µM Ca2+i. n = 4–6 patches; each patch was excised from a different cell. *, different from control (P < 0.05); **, different from control (P < 0.01). Data are expressed as mean ± SEM.](https://cdn.rupress.org/rup/content_public/journal/jgp/148/5/10.1085_jgp.201611594/5/jgp_201611594_fig5.jpeg?Expires=1771735484&Signature=yEWKb4z~FE5f-qUEQZx9nGos6cJEZw5qgx42epshZJpr~q80nR5PUc4Ap4-yATMDoTya2WlmoFVQSf8lEblGd4RcYKugds~j95l6FdSEEwytH9y9-lOMvwW7Oib4CltlQtry1xpH0IEVVsBclMuBJR2aaux2Dh9kP7jeMrRdvmSfni6EJndbS3eBSAL~S8-6YqW7DsfFDVtvvC~ztBMdssO0BnEvJtWM68doN3PK5yLNF-ALYR9OjMTdBgU~AO5KTlh8T7fnGEmOYyywys4H0DFT3gsrys6ZtMlSTMctK1r5F98KUlZMMbJySNY0b5T9RE7zbxSaPXMlBnf~zltpQg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The ethanol response of β2-IR–containing BK channels is similar to the ethanol response of cbv1+β1 channels. (A) V0.5 versus [Ca2+]i plot showing that the activation to inhibition crossover for ethanol effect on cbv1+β2-IR channels occurs at ≈3 µM Ca2+i, as found with cbv1±β1 (Fig. 3 D) and wt β2 (Fig. 4 C). (B) Bar graph showing ethanol-induced change in V0.5 values from control obtained at 0.3 and 100 µM Ca2+i. n = 4–6 patches; each patch was excised from a different cell. *, different from control (P < 0.05); **, different from control (P < 0.01). Data are expressed as mean ± SEM.
