Behavioral deficits in TMEM16B KO mice. (A) WT and KO mice had to locate an Oreo cookie buried in the bedding of their cage. Experiments were performed once a day over 5 d, and on the sixth day the cookie was placed on top of the bedding. (B) After 1 wk on normal diet, the same mice were exposed to a series of odors that were known (Oreo and chow) or novel (peanut, cheese, or chocolate) to them. Mann-Whitney U test: *, P < 0.05; **, P < 0.01; ***, P < 0.001. Mean ± SEM from 11 WT and 13 KO mice.