Figure 1.
![Figure 1. Schematic representation of the MCU complex composition. Mitochondrial Ca2+ uptake is controlled by a multiprotein complex composed of the pore-forming subunits MCU and MCUb together with MICU1, MICU2, and EMRE. In resting conditions (left), MICU1/MICU2 heterodimers act as the MCU gatekeeper, because of the inhibitory effect of MICU2. Once Ca2+ signaling is activated (right), the increase in cytosolic [Ca2+] induces a conformational change in the dimer that releases MICU2-dependent inhibition. At the same time, MICU1 acts as a cooperative activator of the channel and thus stimulates the channel activity. Red dots indicate Ca2+.](https://cdn.rupress.org/rup/content_public/journal/jgp/148/5/10.1085_jgp.201611680/5/jgp_201611680_fig1.jpeg?Expires=1773532639&Signature=P7Wbm7ak6E9wV4zAszY~00EF~P20EIz5qt5m8ACHkdzXno6dqLxWMvY6D6rqY08C-wFmkMlzWVnYA6iOKqj5-VxpuC2Oxwjv9luf3lfiDyVfFBbLTbGqvO5kzWlU7tk~sfcAvAN86axXIf50AKUoeCrtJB84TNcbEQt0yGDIhbucngxzSeTAmd2IkrBnqmcx8qD3Lp859aaOjVMg0-nJtjhXloEb2rbMReuhQTzwX1I-yZ2kfhBjV6Jg3V3k2yCipmBMGAkC27mHC6WgIBJ2bgJhKnzhDVO5J7ywaWXIx-I~Przy9XfPy1JzzYV~isfZD~g7E8-CKJC5m08XFR0Kww__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Schematic representation of the MCU complex composition. Mitochondrial Ca2+ uptake is controlled by a multiprotein complex composed of the pore-forming subunits MCU and MCUb together with MICU1, MICU2, and EMRE. In resting conditions (left), MICU1/MICU2 heterodimers act as the MCU gatekeeper, because of the inhibitory effect of MICU2. Once Ca2+ signaling is activated (right), the increase in cytosolic [Ca2+] induces a conformational change in the dimer that releases MICU2-dependent inhibition. At the same time, MICU1 acts as a cooperative activator of the channel and thus stimulates the channel activity. Red dots indicate Ca2+.
