Figure 1. In vivo cardiac sarcomere imaging system. (A) Schematic of the microscopic system. An example of the open-chest mouse is shown on the left (bar, 10 mm). (B) Illustration showing experimental surgery for the expression of α-actinin–AcGFP in the heart in vivo. (C; left) Epi-illumination image of the heart at rest isolated from the mouse with the ADV injection (observed by a 2× lens). Dashed line, outer edge of the heart. Bar, 2 mm. (Right) Confocal image of the myocytes in the isolated perfused heart at rest (observed by a 60× lens). Bar, 10 µm.
Figure 1.

In vivo cardiac sarcomere imaging system. (A) Schematic of the microscopic system. An example of the open-chest mouse is shown on the left (bar, 10 mm). (B) Illustration showing experimental surgery for the expression of α-actinin–AcGFP in the heart in vivo. (C; left) Epi-illumination image of the heart at rest isolated from the mouse with the ADV injection (observed by a 2× lens). Dashed line, outer edge of the heart. Bar, 2 mm. (Right) Confocal image of the myocytes in the isolated perfused heart at rest (observed by a 60× lens). Bar, 10 µm.

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