Figure 1. Chemical structures and enzymatic synthesis of melatonin from 5-HT. The AANAT (aralkylamine NAS) enzyme catalyzes the rate-limiting N-acetylation of 5-HT to give the intermediate NAS. The HIOMT enzyme methylates NAS to yield the hormone melatonin.
Figure 1.

Chemical structures and enzymatic synthesis of melatonin from 5-HT. The AANAT (aralkylamine NAS) enzyme catalyzes the rate-limiting N-acetylation of 5-HT to give the intermediate NAS. The HIOMT enzyme methylates NAS to yield the hormone melatonin.

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