Figure 10.
![Figure 10. Predicted changes in ΔG associated with Ae4 transport assuming that the cation transport pathway does not distinguish between Na+ and K+. (A) ΔG values calculated assuming a 1:1:2 stoichiometry of Cl−:K+ (Na+):HCO3−. The intracellular Cl− (left) and HCO3− (right) were individually changed (from 0.5 to 150 mM) while the other concentrations were kept fixed at either [Cl−]i = 50.1 mM or [HCO3−]i = 19 mM. (B) Proposed model for Ae4-mediated Cl− uptake in secretory acinar cells.](https://cdn.rupress.org/rup/content_public/journal/jgp/147/5/10.1085_jgp.201611571/5/jgp_201611571_fig10.jpeg?Expires=1773532068&Signature=3yI7nImYhd33tjno7o1FkGIHitcw6R969Rby~PN~H6wgdKWFFXgXEWYRT-KE7BkqkexSehxqODwF8UoJqtZUunafXegU0UIcgXMJAHE7SnbZZKTgtCqC7j9BaUwCpez6zvnJPmpwnNyurN6waVM-tlDvtBc2LAsAIrngklYgUZSIULyCOaofrZDjNLUtPkAfoyTusioMhtLzqjsWRUhnTU41qKZVC3w4bIZsldkG7LRRt0ybBqc0CfxoNbfFevrdzWdDeoxxwGb9f89IT2U5GAz0mU75CKb-phzJvSK7khuVJ1E8oRosYC4fuA1avlX-klKdtZEukAIWfYGlVvOffA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Predicted changes in ΔG associated with Ae4 transport assuming that the cation transport pathway does not distinguish between Na+ and K+. (A) ΔG values calculated assuming a 1:1:2 stoichiometry of Cl−:K+ (Na+):HCO3−. The intracellular Cl− (left) and HCO3− (right) were individually changed (from 0.5 to 150 mM) while the other concentrations were kept fixed at either [Cl−]i = 50.1 mM or [HCO3−]i = 19 mM. (B) Proposed model for Ae4-mediated Cl− uptake in secretory acinar cells.
