Figure 7.
![Figure 7. Predicted changes in ΔG associated with Ae4 activity. ΔG values calculated for Ae4 transport activity assuming stoichiometries of Cl−:Na+:HCO3− as 1:1:2 (top row), 1:2:3 (middle row), and 2:1:3 (bottom row), respectively. The intracellular Cl− (left column), Na+ (middle column), and HCO3− (right column) were individually changed (from 0.5 to 150 mM) while the other concentrations were kept fixed at [Cl−]i = 50.1 mM, [Na+]i = 15.5 mM, or [HCO3−]i = 19 mM.](https://cdn.rupress.org/rup/content_public/journal/jgp/147/5/10.1085_jgp.201611571/5/jgp_201611571_fig7.jpeg?Expires=1773504675&Signature=kaZIVgByOCO1c9fz2LG6HUVH3BlWYozgsHgMX5Sz11kuEg2pPrSLZkux7jX4Tt64FQ6yNbkm9LFqEWNxWmITIkQdjgc8OwHS8nCuiHJbZtg7O3WD4GEWdkKoCxlQxKwfwV73ycGsue061hXDXkEOX1hshmazM9r2~UOCRE3R61LgIIFqI0ctmhIdDAh8~JwT1C9YQQVCuYqHIBpWfhSoVtrn-wHEFDxl3pt4qe~DcOBekxcccbrkn2J68oJgG2Qe4XAfbHMvC8guQXhFHIhmMB9KPBzw3vQRGCgS5mpNR~VDtTFUbqT7V78yRKektd5h7L-Robmph2Epnl7chqPdng__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Predicted changes in ΔG associated with Ae4 activity. ΔG values calculated for Ae4 transport activity assuming stoichiometries of Cl−:Na+:HCO3− as 1:1:2 (top row), 1:2:3 (middle row), and 2:1:3 (bottom row), respectively. The intracellular Cl− (left column), Na+ (middle column), and HCO3− (right column) were individually changed (from 0.5 to 150 mM) while the other concentrations were kept fixed at [Cl−]i = 50.1 mM, [Na+]i = 15.5 mM, or [HCO3−]i = 19 mM.
