Calcin-modified RyR currents. Time-averaged flux carried by open control and calcin-modified RyR channels was estimated from the all points histograms presented in Xiao et al. (2016). These flux determinations are the sum of the full and subconductance currents (open probability considered) and have been normalized to the control value. The average of these eight calcin-modified current determinations is 185% that of the drug-free control RyR.