Figure 6.
Figure 6. Activation parameters for mutations at S1 HCR locus in hNaV1.4. (A) Traces shown are responses to depolarization to 0, 20, 40, and 60 mV for mutations in domains I–III. Plots in B, D, and F show I-V relations for mutations in these domains; plots in C, E, and G show activation kinetics. Values represent mean ± SEM (error bars) from 11–24 experiments. Additional panels are shown for g-V relations for hNaV1.4 and mutations of the HCR in domain I (H), domain II (I), and domain III (J). Boltzmann fits to each plot are shown by dotted lines. Refer to the image caption for details.

Activation parameters for mutations at S1 HCR locus in hNaV1.4. (A) Traces shown are responses to depolarization to 0, 20, 40, and 60 mV for mutations in domains I–III. Plots in B, D, and F show I-V relations for mutations in these domains; plots in C, E, and G show activation kinetics. Values represent mean ± SEM (error bars) from 11–24 experiments. Additional panels are shown for g-V relations for hNaV1.4 and mutations of the HCR in domain I (H), domain II (I), and domain III (J). Boltzmann fits to each plot are shown by dotted lines.

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