Pore profile of the ELIC-GLIC chimera and GLIC structures. (A) Water-accessible region of the pore as determined by the MOLE PyMOL plugin (Petřek et al., 2007). Two subunits are shown, with residues lining the ion permeation pathway represented as sticks. (B) A close-up view of diagonal M2 helices. (C) Pore radius along the channel axis in the ELIC-GLIC chimera and in the GLIC-closed (PDB accession no. 4NPQ) and -open (PDB accession no. 4HFI) forms calculated using MOLE software (Petřek et al., 2007).