Role of circumferential stretch in the cyclic transmural pressure–induced vasodilation. (A) The representation of the decrease in P_int during BK-induced endothelium-dependent vasodilation. P_ext was equal to zero. (B) At isovolumic condition, e.g., approximately constant diameter during cyclic transmural pressure, the cyclic transmural pressure failed to elicit integrin-mediated endothelium-dependent vasodilation in both coronary and skeletal muscular small arterial segments. CAP_int, intraluminal pressure of coronary small arterial segment; SMAP_int, intraluminal pressure of skeletal muscular small arterial segment.