EC in the TRP and Kv pore domains. (A) EC maps of the TRP pore domain, colored as in Fig. 3. (C) Intrasubunit ECs mapped onto a TRPV1 monomer. (E and G) Intersubunit ECs mapped onto the tetrameric TRPV1 pore from the side (E) and from above (G). (B, D, F, and H) Analogous figures for the Kv channels, mapped onto the structure of the paddle chimera pore.