Single-site statistics of the TRP and Kv pore domain. (A) Aligned sequence logos of the TRP and Kv pore domain. Positions with H_rel(X(i)||Q_ref) > 1.25 are marked with an asterisk. High relative entropy (>1.25 nats) positions are displayed on the TRPV1 pore domain structure (B) and paddle chimera pore domain structure (C) in space-filling representation. The following color code has been used for representing different structural elements of the channels: purple, S4–S5 linker and S5; radiant orchid, pore helix; magenta, S6 for TRPV1; steel blue, S4–S5 linker and S5; green, pore helix; indigo, S6 for paddle chimera.