Intersubunit coevolution between the sensor and domain of TRP and Kv channels. (A) EC map of the TRP intersubunit interface overlayed on the contact map TRPV1. To minimize the number of parameters, only the contacting S1 and S4 helices and the pore domain were used in the model of the interface. The EC map is colored as in Fig. 3. (B) Cartoon representation of the structurally aligned TM region of TRPV1 (magenta) and the paddle chimera (blue). Arrows illustrate the counterclockwise shift in the TRP-sensor domain with respect to the paddle chimera. Residues making up the coevolving intersubunit interfaces in both channels are represented as colored surfaces. (C) EC map of the Kv intersubunit interface overlayed on the contact map of the paddle chimera.