Networks of ECs in the TRP- and Kv-sensor domains. (A) The EC map for the TRP-sensor domain overlayed on the contact map of the apo TRPV1-sensor domain. In all EC maps, the axes represent the primary structure of the sensor domain. In the lower triangle, contacting noncoupled positions are gray, noncontacting coupled positions are green, and contacting coupled positions are red (these are of greatest interest to the present study). (B) Cartoon representation of the TRP sensor with contacting, coupled pairs connected with bars. (C) The EC map for the Kv-sensor domain overlayed on the contact map of the paddle chimera VSD. (D) Cartoon representation of the Kv sensor with coupled contacts mapped.