Rods secrete RdCVF, which bind to basigin-1 on cones to stimulate glucose uptake and aerobic glycolysis, promoting cone survival. Loss of rods (and thereby RdCVF) leads to cone degeneration. (Reprinted from Cell, 161, J. Krol and B. Roska, Rods feed cones to keep them alive, 706–708, 2015, with permission from Elsevier.)