Figure 8. SMase D suppresses IL-2 and TNF production. IL-2 and TNF concentrations (error bars represent means ± SEM; n = 5) in cell culture supernatants of human T lymphocytes stimulated with CD3 and CD28 antibody-coated beads in the presence of SMase D (red) or catalytically inactive enzyme (CON, black). Asterisks denote statistically significant comparisons as detailed in Materials and methods.
Figure 8.

SMase D suppresses IL-2 and TNF production. IL-2 and TNF concentrations (error bars represent means ± SEM; n = 5) in cell culture supernatants of human T lymphocytes stimulated with CD3 and CD28 antibody-coated beads in the presence of SMase D (red) or catalytically inactive enzyme (CON, black). Asterisks denote statistically significant comparisons as detailed in Materials and methods.

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