Figure 3. Thermodynamic mutant cycle analysis for TRPV1-WT versus TRPV1-R721A (down arrows) and PI(4,5)P2 versus PI(4)P (horizontal arrows). Values were calculated using the equation ΔG = −RTlnK, where the EC50 for activation by phosphoinositide was used as an approximation for K.
Figure 3.

Thermodynamic mutant cycle analysis for TRPV1-WT versus TRPV1-R721A (down arrows) and PI(4,5)P2 versus PI(4)P (horizontal arrows). Values were calculated using the equation ΔG = −RTlnK, where the EC50 for activation by phosphoinositide was used as an approximation for K.

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