Analysis of calcium waves. (A) The relationship between the frequency of triggered sparks and the length of wave events. Best overall linear fit (R_P = 0.91) is shown as a solid black line. Black, red, green, and blue symbols correspond to parameter groups LA, RyR-Act, RyR, and CaH, respectively (see section Quantitative relationships characterizing the propensity to form calcium waves for explanation of groups), and the corresponding dashed lines show the best linear fits for individual groups. (B) The calcium dependence of the fraction of waves terminated by propagation failure (red), by collision of two waves (black), or by refractoriness (blue). Linear fits of the calcium dependence are shown by lines. (C–E) The fraction of calcium waves terminated by propagation failure (C), by wave collision (D), and by refractoriness (E) for different groups of model parameter changes (see text for explanation of groups). Significant differences between groups are shown by horizontal black lines (two-way ANOVA with Bonferroni correction; P < 0.05). Error bars represent mean ± SEM.