The contribution of calcium-handling properties to the properties of triggered sparks in control, under conditions when the propensity to form calcium waves is increased by changes in RyR gating, and upon changes in D_Ca, j_Ca, and τ_d. (A) The relative effect of D_Ca (red dashed line), j_Ca (green dashed line), and τ_d (blue dashed line) on the frequency of triggered sparks (black solid line). (B) The relative effect of D_Ca (red dashed line), j_Ca (green dashed line), τ_d (blue dashed line), and $∂Can−O$ (magenta dashed line) on the increase of the number of open RyRs in triggered sparks (black solid line). Individual changes of simulation parameters are denoted at the top of the figure.