The effect of the properties of spontaneous sparks on the predicted properties of triggered sparks in control and under conditions when changes in RyR gating increase the propensity to form calcium waves. (A) The relative effect of ∂_Caϕ_spark (red dashed line) and $n−O$ (blue dashed line) on the frequency of triggered sparks (black solid line). (B) The relative effect of ∂_Caϕ_spark (red dashed line), $n−O$ (blue dashed line), and $∂Can−O$ (magenta dashed line) on the increase of the number of open RyRs in triggered sparks (black solid line). Individual changes of simulation parameters are denoted at the top of the figure.