Figure 2.
![Figure 2. The effect of simulated EGTA removal on propagation of calcium waves. (A) Simulated calcium sparks at 0.05 µM of cytosolic [Ca2+] and at different values of the parameter n, used for simulating changes of EGTA concentration (see section Spontaneous diastolic calcium waves simulated using the aHTG model of the RyR). (B) The calcium dependence of the frequency of triggered sparks (ΔϕSpark) in control and for n = 2 and n = 3 (black, red, and blue symbols, respectively). (C) The calcium dependence of the average number of open RyRs in spontaneous (open symbols) and triggered sparks (closed symbols) in control (n = 1) and for n = 2 and n = 3 (black, red, and blue symbols, respectively). Error bars represent mean ± SEM.](https://cdn.rupress.org/rup/content_public/journal/jgp/145/6/10.1085_jgp.201411281/5/jgp_201411281_fig2.jpeg?Expires=1767745627&Signature=UbBDZFGzfqosxSBuj9~qH~MCHyPKPlMkZlbdD-p9gFLaOZ-bGzsMY5e1xWrkMJ-XZuC8WnnP22czD60~cvq3a7cVM-kNkttKPPtqWt3l20gn28X~aWwLLnSdaoTaIVgzKX1ajjeTDjFMRQBAYDk6~orGGgKVO20kkP5MTy4wyTWADSIAuyzUMsGGVodaN~F~2I5TQrafVxQ1s8O-xZgJjhWUpCSxWql81DS00k2xoxuHtnDUzOVvM5FkPQ-D1kBYeZTZOeZz~3VKe7zbpzOGsJvko-fOFmcNtU4GJOFylVQTpxWLFk4oRC8~jAJap~9dCX8bZFPG0ERbl7BtKKSvoA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The effect of simulated EGTA removal on propagation of calcium waves. (A) Simulated calcium sparks at 0.05 µM of cytosolic [Ca2+] and at different values of the parameter n, used for simulating changes of EGTA concentration (see section Spontaneous diastolic calcium waves simulated using the aHTG model of the RyR). (B) The calcium dependence of the frequency of triggered sparks (ΔϕSpark) in control and for n = 2 and n = 3 (black, red, and blue symbols, respectively). (C) The calcium dependence of the average number of open RyRs in spontaneous (open symbols) and triggered sparks (closed symbols) in control (n = 1) and for n = 2 and n = 3 (black, red, and blue symbols, respectively). Error bars represent mean ± SEM.
