Figure 1.
![Figure 1. Calcium sparks at different cytosolic [Ca2+]. (A) Typical examples of simulated calcium sparks at the indicated cytosolic [Ca2+]. (B) Calcium dependence of spark frequency. Black squares, experimental data (Lukyanenko and Gyorke, 1999), assuming 36.4 release sites per 100-µm line scan (Zahradníková et al., 2010; Janíček et al., 2012). Line, theoretical calcium dependence of spontaneous calcium spark frequency calculated from Eq. 2 using parameters from Tables 1 and 2. Red circles, simulated data (error bars are smaller than the size of the symbols). Error bars represent mean ± SEM.](https://cdn.rupress.org/rup/content_public/journal/jgp/145/6/10.1085_jgp.201411281/5/jgp_201411281_fig1.jpeg?Expires=1767780117&Signature=SFqfYvqtmmqlAc-j9-BeISk62kxMWi1YaHAIdianaqF0KvuxaHNAoMv-DdalAGsegzfqCHEQgmXujBUWTA~6yE6Oj4B8YcZZ1SGceD~eLCH1WWBATb5zX~5xYrvXYXecLW8bPO5CKS09ITIIFVW72IezGjcdDeWOGXaj40vZFJd~wlv0kObewxKMpJ-w-RGxmhpC8EHJB~QwRI-SWRXT0pCXTU0ZkH2yP1mmRmsysLS0ZFmlGo6Iy7yKfe2SC6cPTMWp-P2k1E~s5lUAi3ZUCiFbTxtT63fgVWwRVght3bSy52U1cLMPuB-4fCwqRL7iRoR0QC4RXvah0XAUVa0kOw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Calcium sparks at different cytosolic [Ca2+]. (A) Typical examples of simulated calcium sparks at the indicated cytosolic [Ca2+]. (B) Calcium dependence of spark frequency. Black squares, experimental data (Lukyanenko and Gyorke, 1999), assuming 36.4 release sites per 100-µm line scan (Zahradníková et al., 2010; Janíček et al., 2012). Line, theoretical calcium dependence of spontaneous calcium spark frequency calculated from Eq. 2 using parameters from Tables 1 and 2. Red circles, simulated data (error bars are smaller than the size of the symbols). Error bars represent mean ± SEM.
