Schematic representing plasticity of the dDATmfc ligand-binding pocket bound to the substrates dopamine or 4-dichlorophenethylamine (DCP) (e) or the inhibitors cocaine or nortriptyline (f). (Reprinted by permission from Macmillan Publishers, Ltd. K.H. Wang et al. Nature. http://dx.doi.org/10.1038/nature14431, copyright 2015.)

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