Figure 3. PIP2 increases Po at negative voltages without Ca2+. (A) Representative single-channel openings at −120 mV of Slo1 without Ca2+ before and after the application of 10 µM PIP2. In each condition, 25 data traces are shown superimposed. This patch contained ∼350 channels. (B) Representative single-channel openings at −120 mV of Slo1 + β1 without Ca2+ before and after the application of 10 µM PIP2. 60 data traces are shown superimposed, and the patch contained ∼250 channels. (C) Comparison of Po changes in Slo1 and Slo1 + β1 by 10 µM PIP2. (D) Fractional changes in Po by 10 µM PIP2; n = 7 and 8 for Slo1 and Slo1 + β1, respectively. All results were obtained without Ca2+. Error bars represent mean ± SEM.
Figure 3.

PIP2 increases Po at negative voltages without Ca2+. (A) Representative single-channel openings at −120 mV of Slo1 without Ca2+ before and after the application of 10 µM PIP2. In each condition, 25 data traces are shown superimposed. This patch contained ∼350 channels. (B) Representative single-channel openings at −120 mV of Slo1 + β1 without Ca2+ before and after the application of 10 µM PIP2. 60 data traces are shown superimposed, and the patch contained ∼250 channels. (C) Comparison of Po changes in Slo1 and Slo1 + β1 by 10 µM PIP2. (D) Fractional changes in Po by 10 µM PIP2; n = 7 and 8 for Slo1 and Slo1 + β1, respectively. All results were obtained without Ca2+. Error bars represent mean ± SEM.

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