Figure 3.
Figure 3. β1 TM1 and TM2 cross-linking to α S0–S5. (A) Cleavage at HRV-3C site 2 removed the ∼88-kD C-terminal domain. (B) Cross-linking of α and β1 and cleavage at the HRV-3C site resulted in an HA-tagged fragment of ∼65 kD (42 kD + β1). (C) Cross-linking extents between TM1 positions (left legend) or TM2 positions (right legend) and positions in S0, S1, S2–S3, and S4–S5 (vertical axes). Calculation of cross-linking extents is described in Materials and methods. Mean ± SEM.

β1 TM1 and TM2 cross-linking to α S0–S5. (A) Cleavage at HRV-3C site 2 removed the ∼88-kD C-terminal domain. (B) Cross-linking of α and β1 and cleavage at the HRV-3C site resulted in an HA-tagged fragment of ∼65 kD (42 kD + β1). (C) Cross-linking extents between TM1 positions (left legend) or TM2 positions (right legend) and positions in S0, S1, S2–S3, and S4–S5 (vertical axes). Calculation of cross-linking extents is described in Materials and methods. Mean ± SEM.

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