Model for TRAAK gating. Left shows the closed conformation, with an acyl chain extending into the cavity to sterically block conduction; TM4 rotation (right) blocks lipid access to allow conduction. Insets show change in cross-sectional area, which together with reduced membrane bending in the open conformation, promotes channel opening with increased membrane tension (Reprinted by permission from Macmillan Publishers, Ltd. S.G. Brohawn et al. Nature. http://dx.doi.org/10.1038/nature14013, copyright 2014.)

Model for TRAAK gating. Left shows the closed conformation, with an acyl chain extending into the cavity to sterically block conduction; TM4 rotation (right) blocks lipid access to allow conduction. Insets show change in cross-sectional area, which together with reduced membrane bending in the open conformation, promotes channel opening with increased membrane tension (Reprinted by permission from Macmillan Publishers, Ltd. S.G. Brohawn et al. Nature. http://dx.doi.org/10.1038/nature14013, copyright 2014.)

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal