Figure 7.
Figure 7. Electrostatic effects at interfaces alter ENaC activity. (A and B) Representative current traces in Xenopus oocytes (voltage clamped to −60 mV) expressing wild-type ENaC (blue) or αβV85CγENaC (black) treated with MTSET (white bar, A) or MTSES (white bar, B). ENaC current was determined by block with 10 µM amiloride (Amil, black bars). (C and D) Percent change in ENaC current after treatment with MTSET (ET+) or MTSES (ES−) for cells expressing αβV85CγENaC (C) or αL120CβγENaC (D). Mean ± SEM is shown (n = 12; *, P < 0.0002).

Electrostatic effects at interfaces alter ENaC activity. (A and B) Representative current traces in Xenopus oocytes (voltage clamped to −60 mV) expressing wild-type ENaC (blue) or αβV85CγENaC (black) treated with MTSET (white bar, A) or MTSES (white bar, B). ENaC current was determined by block with 10 µM amiloride (Amil, black bars). (C and D) Percent change in ENaC current after treatment with MTSET (ET+) or MTSES (ES−) for cells expressing αβV85CγENaC (C) or αL120CβγENaC (D). Mean ± SEM is shown (n = 12; *, P < 0.0002).

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