Figure 4.
Figure 4. Length dependence of cross-linking. Percent change in ENaC current in Xenopus oocytes expressing αβγENaC (black), αK477Cβγ (green), αβV85Cγ (red), or αK477CβV85CγENaC (blue) induced by treatment with cross-linking reagents of different lengths (“x” indicates the number of atoms in the linker backbone): MTS-2-MTS (5.2 Å), MTS-4-MTS (7.8 Å), MTS-6-MTS (10.4 Å), MTS-11-O3-MTS (16.9 Å), and MTS-14-O4-MTS (20.8 Å). Mean ± SEM is shown (n = 3–15; some data symbols and error bars are hidden by other data symbols).

Length dependence of cross-linking. Percent change in ENaC current in Xenopus oocytes expressing αβγENaC (black), αK477Cβγ (green), αβV85Cγ (red), or αK477CβV85CγENaC (blue) induced by treatment with cross-linking reagents of different lengths (“x” indicates the number of atoms in the linker backbone): MTS-2-MTS (5.2 Å), MTS-4-MTS (7.8 Å), MTS-6-MTS (10.4 Å), MTS-11-O3-MTS (16.9 Å), and MTS-14-O4-MTS (20.8 Å). Mean ± SEM is shown (n = 3–15; some data symbols and error bars are hidden by other data symbols).

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