Response profiles of rat OR-I7 and mouse OR-EG expressed in various assay systems. The response profiles of a given OR can vary depending on the assay system. For rat OR-I7 and mouse mOR-EG, tested but inactive compounds are not included in this figure unless the compound showed agonist or antagonist activity in at least one of the assays shown. For rat OR-I7, only select agonists are reported. See Araneda et al. (2000) for a more complete listing of OR-I7 agonists. Blue boxes, heat map of reported EC₅₀ values; darkest blue, <0.1 µM; lightest blue, 660 µM; black boxes, agonist but no EC₅₀ reported; orange boxes, partial agonist; red boxes, antagonist; white boxes, tested but inactive; Int, intrinsic imaging; Ca²⁺, calcium imaging; I, current; luc, luciferase; Seap, secreted alkaline phosphatase; OB, olfactory bulb; OSN, olfactory sensory neuron; COS, African green monkey cells; Ocy, Xenopus oocytes; H3A, Hana3A cells; HEK, human embryonic kidney cells. References: 1, Belluscio et al. (2002); 2, Araneda et al. (2004); 3, Peterlin et al. (2008); 4, Kurland et al. (2010); 5, Levasseur et al. (2003); 6, Bozza et al. (2002); 7, Oka et al. (2006); 8, Repicky and Luetje (2009); 9, Zhuang and Matsunami (2007); 10, Baud et al. (2011); 11, Katada et al. (2005); 12, Oka et al. (2004a,b).