Figure 2.
Figure 2. Response to capsaicin and voltage of representative I696X and W697X mutants. (A) I-V curves of ionic currents evoked by 100 µM capsaicin from representative I696X mutants. (B) Current density values at +80 and −80 mV of I696X mutants in the presence of 100 µM capsaicin. (C) I-V curves of ionic currents activated by capsaicin at 100 µM from representative W697X mutants. (D) Current density values at +80 and −80 mV of W697X mutants in the presence of 100 µM capsaicin. I-V curves were obtained using a voltage ramp protocol from −80 mV to +160 mV in 350 ms. The current density of TRPV1 wild type, I696I (I), and W697W (W) species was obtained in the presence of 1 µM capsaicin. Data are given as mean ± SEM (error bars), with n (number of cells) ≥ 5.

Response to capsaicin and voltage of representative I696X and W697X mutants. (A) I-V curves of ionic currents evoked by 100 µM capsaicin from representative I696X mutants. (B) Current density values at +80 and −80 mV of I696X mutants in the presence of 100 µM capsaicin. (C) I-V curves of ionic currents activated by capsaicin at 100 µM from representative W697X mutants. (D) Current density values at +80 and −80 mV of W697X mutants in the presence of 100 µM capsaicin. I-V curves were obtained using a voltage ramp protocol from −80 mV to +160 mV in 350 ms. The current density of TRPV1 wild type, I696I (I), and W697W (W) species was obtained in the presence of 1 µM capsaicin. Data are given as mean ± SEM (error bars), with n (number of cells) ≥ 5.

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