Body temperatures after SARS-CoV-2 inoculation of 19 vaccinated aged rhesus macaques on day of infection and for 6 consecutive d afterward. Calendar dates are on top, animal id and group number labels on the right-hand side. Orange lines indicate the daily baseline temperature profile derived from a multiday window before virus inoculation in which no biotechnical interventions occurred. The blue line is the temperature of each animal after infection. Top: Body temperatures of the 10¹¹-vp Ad26.COV2.S group. Middle: Body temperatures of the 5 × 10¹⁰–vp Ad26.COV2.S group. Bottom: Body temperatures of the pooled control animal group. p.i., post infection.