Figure 5.
Figure 5. Characteristics of the 3R channel. (A and B) Current families for R362Q (A) and 3R channel (B) when stepping the membrane voltage from −80 mV to voltages between −80 and 40 mV (−60 and 60 mV for 3R channel) in 5-mV increments in control solution, pH 7.4, at a frequency of 0.2 Hz. (C) Representative current traces at pH 7.4 for 3R in control solution (black) and in 70 µM DHA (red) for a voltage corresponding to 10% of Gmax in control solution (i.e., 10 mV). The increment in current amplitude is >10-fold. (D) Representative G(V) curves. Same cell as in C (control, black symbols; DHA, red symbols). ΔG(V)DHA = −22.1 mV in this example.

Characteristics of the 3R channel. (A and B) Current families for R362Q (A) and 3R channel (B) when stepping the membrane voltage from −80 mV to voltages between −80 and 40 mV (−60 and 60 mV for 3R channel) in 5-mV increments in control solution, pH 7.4, at a frequency of 0.2 Hz. (C) Representative current traces at pH 7.4 for 3R in control solution (black) and in 70 µM DHA (red) for a voltage corresponding to 10% of Gmax in control solution (i.e., 10 mV). The increment in current amplitude is >10-fold. (D) Representative G(V) curves. Same cell as in C (control, black symbols; DHA, red symbols). ΔG(V)DHA = −22.1 mV in this example.

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