Figure 2.
Figure 2. Single-channel openings at negative voltages in the absence of intracellular Ca2+. (A) Representative hSlo1 openings at −120 mV before (top) and after (bottom) the addition of DHA. This patch contained ∼140 channels, and 20 40-ms segments are shown superimposed in each condition. (B) Po before (blue) and after (red) DHA addition (top) and fractional increases in Po by DHA (bottom) at different voltages. n = 6–9, depending on the voltage. (C) Mean open durations (MODs) before (blue) and after (red) DHA application (top) and fractional increases in MODs by DHA at different voltages (bottom). n = 5. DHA was applied at 3 µM.

Single-channel openings at negative voltages in the absence of intracellular Ca2+. (A) Representative hSlo1 openings at −120 mV before (top) and after (bottom) the addition of DHA. This patch contained ∼140 channels, and 20 40-ms segments are shown superimposed in each condition. (B) Po before (blue) and after (red) DHA addition (top) and fractional increases in Po by DHA (bottom) at different voltages. n = 6–9, depending on the voltage. (C) Mean open durations (MODs) before (blue) and after (red) DHA application (top) and fractional increases in MODs by DHA at different voltages (bottom). n = 5. DHA was applied at 3 µM.

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