Q ON decreases as a function of frequency. (A) QON values were normalized with respect to the initial QON (QON,0) and plotted against the trial number, which were evoked at the frequency indicated on the right. The time course of the QON decay was fitted to two exponentials (red traces). (B) Fitted fraction of QON loss related to each component. The weight of the slow component increases as a function of pulsing frequency, whereas the fast component tended to saturate above 2 Hz. The slow component has no contribution at 0.5 Hz and lower frequencies. (C) Fitted time constants for the fast and slow components decrease exponentially as a function of frequency, with a tendency to saturate at about 2 Hz. Error bars are SD.