Figure 5.
Figure 5. Mutant R229H. (A) Currents recorded from Xenopus oocytes expressing the mutant R217Q-R229H-C363S were evoked by applying test pulses ranging from −120 to 80 mV. Test pulses were delivered from an HP of −90 mV. The amplitude of the current at the beginning of the test pulse decreased at pHEXT 5.0. The amplitude of the tail sensing currents increased as pHEXT decreased (red arrows). (B) Normalized ITAIL-V curves at pHEXT 7.4, 6.5, and 5.0. Currents from individual experiments were normalized with respect to the module of the maximum tail current observed at pHEXT 7.4. Normalized tail current (I/IMAX) increased 8 ± 2 as pHEXT decreased from 7.4 (left) to 5.0 (right). Error bars are SD.

Mutant R229H. (A) Currents recorded from Xenopus oocytes expressing the mutant R217Q-R229H-C363S were evoked by applying test pulses ranging from −120 to 80 mV. Test pulses were delivered from an HP of −90 mV. The amplitude of the current at the beginning of the test pulse decreased at pHEXT 5.0. The amplitude of the tail sensing currents increased as pHEXT decreased (red arrows). (B) Normalized ITAIL-V curves at pHEXT 7.4, 6.5, and 5.0. Currents from individual experiments were normalized with respect to the module of the maximum tail current observed at pHEXT 7.4. Normalized tail current (I/IMAX) increased 8 ± 2 as pHEXT decreased from 7.4 (left) to 5.0 (right). Error bars are SD.

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