Figure 7.
Ih expression in cultured adult SGNs. (A) Family of representative Ih traces from adult (≥P40, base) WT, Hcn1−/−, and Hcn2−/− SGNs. (B) Normalized Ih activation curves generated by fitting a Boltzmann function to tail currents shown in A. Note the hyperpolarized half-activation voltage shift in Hcn1−/− SGNs compared with WT and Hcn2−/−. (C and D) Summary of conductances (C) and half-activation voltages (D) for 11 WT, 6 Hcn1−/−, and 11 Hcn2−/− SGNs. (E) Summary of Ih fast activation time constants. Error bars equal +1 SD. **, P < 0.01; ***, P < 0.001.