Figure 1.
Figure 1. Sequential versus allosteric models. (A) Allosteric model. In this model, Po is given by the expression: Po = [L(1 + JD + KC + JKCD)4]/[L(1 + JD + KC + JKCD)4 + (1 + J + K + JKE)4]; J = e(−zjF(V−Vh)/RT), with zJ = 0.6 e0, Vh = 168 mV; L = Loe(zLFV/RT), with zL = 0.3 e0 and Lo = 10−6. The values for the allosteric factors were: D = 19, C = 14, and E = 3.8, and the constant Kd = 8.2 µM defines the Ca2+-binding reaction X↔XCa (Orio and Latorre, 2005). (B) A sequential model of the Hodgkin and Huxley type. In this type of model, the open probability (Po) is given by the expression: Po = (1/(1 + J))4, where the equilibrium constant that defines the reaction Resting↔Active of the voltage sensors is defined as: J = e(−zjF(V−Vh)/RT), with zJ = 1.2 e0 and Vh = 20 mV.

Sequential versus allosteric models. (A) Allosteric model. In this model, Po is given by the expression: Po = [L(1 + JD + KC + JKCD)4]/[L(1 + JD + KC + JKCD)4 + (1 + J + K + JKE)4]; J = e(−zjF(V−Vh)/RT), with zJ = 0.6 e0, Vh = 168 mV; L = Loe(zLFV/RT), with zL = 0.3 e0 and Lo = 10−6. The values for the allosteric factors were: D = 19, C = 14, and E = 3.8, and the constant Kd = 8.2 µM defines the Ca2+-binding reaction X↔XCa (Orio and Latorre, 2005). (B) A sequential model of the Hodgkin and Huxley type. In this type of model, the open probability (Po) is given by the expression: Po = (1/(1 + J))4, where the equilibrium constant that defines the reaction Resting↔Active of the voltage sensors is defined as: J = e(−zjF(V−Vh)/RT), with zJ = 1.2 e0 and Vh = 20 mV.

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