Figure 3.
PDE inhibitors increase T* and ThRC lifetime in wild-type ThRCs. (A) ThRCs in AFD neurons recorded with control intracellular saline (top) or with saline containing 200 µM IBMX (middle) or 1 µM BAY-60-7550 (bottom). Arrows indicate the T* for ThRCs in each condition. Vhold = −60 mV and Thold = 20°C. (B) Average T*, half-maximal duration, and peak amplitude. Bars are the mean ± SEM of at least eight recordings in each condition. *, P < 0.05 compared with control.