Figure 6.
Calcium and magnesium block UNC-8(A586T) currents. (A) Example of currents stimulated by voltage steps from −160 to +100 mV in an oocyte injected with UNC-8(A586T); the holding potential was −30 mV. The oocyte was perfused with a physiological NaCl solution containing 1 mM CaCl2 and 2 mM MgCl2. (B) Average current–voltage relationships obtained from currents similar to the ones shown in A (n = 6). (C) The same oocyte shown in A was perfused with the divalent cation–free plus EGTA NaCl solution. (D) Average current–voltage relationship obtained from currents similar to the ones shown in C (n = 6).
