GIRK2 activation by Gβγ. Side (A) and bottom (B) views of the GIRK2-Gβγ-PI(4,5)P2. (C) Model of GIRK rearrangement from the closed to the preopen and open states. (Reprinted by permission from Macmillan Publishers, Ltd. Nature. Reuveny, 498:182–183, copyright 2013.)

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