Figure 15.
![Figure 15. Global analysis applied to limiting conductance states in Scheme 4. Plots of 〈qC〉 and 〈qO〉 are shown for [Ca2+]i = 10−3 µM (solid curves) and 103 µM (dashed curves). The expression for closed- and open-state VM (vertical dashed lines) are given by VM(C) = [ΔGJ1 + ΔGJ2 + ΔWG − kTln(ZCA/ZCR)]/(ΔqJ1 + ΔqJ2) and VM(O) = [ΔGJ1 + ΔGJ2 + ΔWG + ΔWD − kTln(ZOA/ZOR)]/(ΔqJ1 + ΔqJ2). The area of the parallelogram is given by −4(ΔqJ1 + ΔqJ2)LΔVMμ(−) = −4ΔWD. The area of the smaller rectangle is given by −4(ΔqJ1 + ΔqJ2) μΔVM(O) = −4ΔWE.](https://cdn.rupress.org/rup/content_public/journal/jgp/141/1/10.1085_jgp.201210859/4/jgp_201210859_fig15.jpeg?Expires=1773490624&Signature=XUqjvL3fGBppeH72BQLHRQzfJlKaiCfuaSTUNZgPA~ddGGQIbHswTCFLgAx0wIKLy3BsaEDixScpujGeo15BbLF5BpfjBoFEeqZpnlay3Q-lrwtiC-AO6BQSfy8ufl5H~HT4rO0xEwKLsEobnyF2ZPeAWSRRMTmKudl~EzAyRcyDOaitEFObRNMBlaILDnvLxd4F~8ZRSI1HE7TnmxVcFtbjzAQ7kvnvlwyuoLLi51rB7mojtgcuTZxTvyIl1tFRmsV23YLnyHbTn5HrfmxnJ5pxXg-9H5zrPupTBS08VMvvlrcAB6CPQl7hzH8prK9LHkihAwp2yLjVR7c~-Uu3sg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Global analysis applied to limiting conductance states in Scheme 4. Plots of 〈qC〉 and 〈qO〉 are shown for [Ca2+]i = 10−3 µM (solid curves) and 103 µM (dashed curves). The expression for closed- and open-state VM (vertical dashed lines) are given by VM(C) = [ΔGJ1 + ΔGJ2 + ΔWG − kTln(ZCA/ZCR)]/(ΔqJ1 + ΔqJ2) and VM(O) = [ΔGJ1 + ΔGJ2 + ΔWG + ΔWD − kTln(ZOA/ZOR)]/(ΔqJ1 + ΔqJ2). The area of the parallelogram is given by −4(ΔqJ1 + ΔqJ2)LΔVMμ(−) = −4ΔWD. The area of the smaller rectangle is given by −4(ΔqJ1 + ΔqJ2) μΔVM(O) = −4ΔWE.
