Figure 8.
![Figure 8. Charge-per-channel analysis of Monte Carlo–simulated data from Scheme 4. (A) Gating current transient from n = 1,027 channels averaged over 100 traces for a test (ON) pulse from −300 to 300 mV. Simulation conditions were fs = 50 kHz, fc = 10 kHz, and [Ca2+]i = 1.0 µM. The integral of the gating current, measured in femtocoulombs (fC), is superimposed onto the current. (B) Mean–variance plots of ionic currents for ON (300 mV) and OFF (0 mV) pulses from a resting potential of −300 mV and Veq = −102 mV. The fitted curves (smooth parabolas) for this particular simulation yielded N(ON) = 1,106 and N(OFF) = 1,010.](https://cdn.rupress.org/rup/content_public/journal/jgp/141/1/10.1085_jgp.201210859/4/jgp_201210859_fig8.jpeg?Expires=1767810670&Signature=OKrI0-o6xUdmIsvRSqbYe-xBuP6ed0b1WhxxxLO5jCIVLzFh1gHTM2rLKQGsbWdrnIdjaVC31LS6KkOO8MF-Y1Bm83PJaouA1WopVLcMWRzol~iFYEQExTqQVkbaNSMue2jQ~1QXoT97ZBVLf75e3tM6Q-CQgmWV6A8INWR8lwjnG7lq1tp68n9yrG2MU7TjdHzbAr6RiQRpvCwrhHaKsTDUk2SWHTqBOjCWX6GJ8dQMhOG~0f8a3lMik6B2z-WHpanWaBfMwgYNzC77aGLtX4Fq~meOTQqmhNgtzG3fcNvkq6fM6pQunkSo7K4A0cCpXx0rj7tRvb8b5T-lsY6Q5A__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Charge-per-channel analysis of Monte Carlo–simulated data from Scheme 4. (A) Gating current transient from n = 1,027 channels averaged over 100 traces for a test (ON) pulse from −300 to 300 mV. Simulation conditions were fs = 50 kHz, fc = 10 kHz, and [Ca2+]i = 1.0 µM. The integral of the gating current, measured in femtocoulombs (fC), is superimposed onto the current. (B) Mean–variance plots of ionic currents for ON (300 mV) and OFF (0 mV) pulses from a resting potential of −300 mV and Veq = −102 mV. The fitted curves (smooth parabolas) for this particular simulation yielded N(ON) = 1,106 and N(OFF) = 1,010.
